Miki T*†, Okamoto Y†, Ueno-Umegai M, Toyofuku R, Hattori S, Sakaba T. Single-vesicle imaging reveals actin-dependent spatial restriction of vesicles at the active zone, essential for sustained transmission. Proc Natl Acad Sci USA in press.

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Hattori S*, Miki T, Sanjo A, Kobayashi D, Takahara M. SimMolCC: A Similarity of Automatically Detected Bio-Molecule Clusters between Fluorescent Cells. Appl Sci 14: 7958. 2024.

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Igarashi W, Takagi D, Okada D, Kobayashi D, Oka M, Io T, Ishii K, Ono K, Yamamoto H, Okamoto Y*.　Bioinformatic Identification of Potential RNA Alterations on the Atrial Fibrillation Remodeling from Human Pulmonary Veins. Int J Mol Sci 24: 10501. 2023.

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Okada D, Okamoto Y*, Io T, Oka M, Kobayashi D, Ito S, Yamada R, Ishii K, Ono K. Comparative study of transcriptome in the hearts isolated from mice, rats, and humans. Biomolecules 12: 859. 2022.

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Okamoto Y*, Aung NY, Tanaka M, Takeda Y, Takagi D, Igarashi W, Ishii K, Yamakawa M, Ono K. Preferential expression of Ca2+-stimulable adenylyl cyclase III in the supraventricular area, including arrhythmogenic pulmonary vein of the rat heart. Biomolecules 12: 724. 2022 　

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Tran V*†, Miki T*†, Marty A. Three small vesicular pools in sequence govern synaptic response dynamics during action potential trains. Proc Natl Acad Sci USA 119: e2114469119, 2022.

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Tanaka M, Sakaba T, Miki T*. Quantal analysis estimates docking site occupancy determining short-term depression at hippocampal glutamatergic synapses. J Physiol 599: 5301-5327, 2021.

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Fukuda Y, Higashiya M, Obata T, Basaki K, Yano M, Matsumura K, Ono K, Ohba T, Okamoto Y, Nishijima K, Seki S*. Small-volume vitrification and rapid warming yield high survivals of one-cell rat embryos in cryotubes. Biol Reprod 105: 258-266. 2021

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Takahashi K, Ohba T, Okamoto Y, Noguchi A, Okuda H, Kobayashi H, Harada KH, Koizumi A, Ono K, Takahashi T*. E44Q mutation in Nav1.7 in a patient with infantile paroxysmal knee pain: electrophysiological analysis of voltage-dependent sodium current. Heliyon 7: e07396. 2021

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Vandael D†, Okamoto Y†, Borges-Merjane C, Vargas-Barroso V, Suter BA, Jonas P*. Subcellular patch-clamp techniques for single-bouton stimulation and simultaneous pre- and postsynaptic recording at cortical synapses. Nat Protoc 16: 2947-2967. 2021

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Vandael D*†, Okamoto Y†, Jonas P*. Transsynaptic modulation of presynaptic short-term plasticity in hippocampal mossy fiber synapses. Nat Commun 12: 2912. 2021

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Nasu F, Obara Y, Okamoto Y, Yamaguchi H, Kurakami K, Norota I, Ishii K*. Azelnidipine treatment reduces the expression of Cav1.2 protein. Life Sci 269: 119043. 2021.

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Miki T*, Midorikawa M, Sakaba T*. Direct imaging of rapid tethering of synaptic vesicles accompanying exocytosis at a fast central synapse. Proc Natl Acad Sci USA 117: 14493-14502, 2020.

 

Malagon G, Miki T, Tran V, Gomez LC, Marty A*. Incomplete vesicular docking limits synaptic strength under high release probability conditions. Elife 9: e52137, 2020.

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Takagi D, Okamoto Y, Ohba T, Yamamoto H, Ono K*. Comparative study of hyperpolarization-activated currents in pulmonary vein cardiomyocytes isolated from rat, guinea pig, and rabbit. J Physiol Sci 70: 6. 2020

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Okamoto Y, Nagasawa Y, Obara Y, Ishii K, Takagi D, Ono K*. Molecular identification of HSPA8 as an accessory protein of a hyperpolarization-activated chloride channel from rat pulmonary vein cardiomyocytes. J Biol Chem 294: 16049-16061. 2019.

 

Miyano R, Miki T, Sakaba T*. Ca dependence of synaptic vesicle exocytosis and endocytosis at the hippocampal mossy fiber terminal. J Physiol 597: 4373-4386, 2019.

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Miki T*. What we can learn from cumulative numbers of vesicular release events. Front Cell Neurosci 13, 257, 2019.

 

Umehara S, Tan X, Okamoto Y, Ono K, Noma A, Amano A, Himeno Y*. Mechanisms Underlying Spontaneous Action Potential Generation Induced by Catecholamine in Pulmonary Vein Cardiomyocytes: A Simulation Study. Int J Mol Sci 20: 2913. 2019.

 

Miki T*, NakamuraY, Malagon G, Neher E, Marty A*. Two-component latency distributions indicate two-step vesicular release at simple glutamatergic synapses. Nat Commun 9: 3943, 2018.

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Kashino Y, Obara Y*, Okamoto Y, Saneyoshi T, Hayashi Y, Ishii K. ERK5 Phosphorylates Kv4.2 and Inhibits Inactivation of the A-Type Current in PC12 Cells. Int J Mol Sci 19: 2008. 2018

 

Kubota Y*, Sohn J, Hatada S, Schurr M, Straehle J, Gour A, Neujahr R, Miki T, Mikula S, Kawaguchi Y. A carbon nanotube tape for serial-section electron microscopy of brain ultrastructure. Nat Commun 9: 437, 2018.

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Yavari A*, Bellahcene M, Bucchi A, Sirenko S, Pinter K, Herring N, Jung JJ, Tarasov KV, Sharpe EJ, Wolfien M, Czibik G, Steeples V, Ghaffari S, Nguyen C, Stockenhuber A, Clair JRS, Rimmbach C, Okamoto Y, Yang D, Wang M, Ziman BD, Moen JM, Riordon DR, Ramirez C, Paina M, Lee J, Zhang J, Ahmet I, Matt MG, Tarasova YS, Baban D, Sahgal N, Lockstone H, Puliyadi R, de Bono J, Siggs OM, Gomes J, Muskett H, Maguire ML, Beglov Y, Kelly M, Dos Santos PPN, Bright NJ, Woods A, Gehmlich K, Isackson H, Douglas G, Ferguson DJP, Schneider JE, Tinker A, Wolkenhauer O, Channon KM, Cornall RJ, Sternick EB, Paterson DJ, Redwood CS, Carling D, Proenza C, David R, Baruscotti M, DiFrancesco D, Lakatta EG, Watkins H, Ashrafian H*. Mammalian γ2 AMPK regulates intrinsic rate. Nat Commun 8: 1258. 2017.

 

Miki T*, Kaufmann W, Malagon G, Gomez L, Tabuchi K, Watanabe M, Shigemoto R*, Marty A*. Numbers of presynaptic Ca²⁺ channel clusters match those of functionally defined vesicular docking sites in single central synapses. Proc Natl Acad Sci USA 114: E5246-E5255, 2017.

 

Miki T, Malagon G, Pulido C, Llano I, Neher E, Marty A*. Actin- and myosin-dependent vesicle loading of presynaptic docking sites prior to exocytosis. Neuron 91: 808-823, 2016.

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Yaniv Y*, Ahmet I, Tsutsui K, Behar J, Moen JM, Okamoto Y, Guiriba TR, Liu J, Bychkov R, Lakatta EG*. Deterioration of autonomic neuronal receptor signaling and mechanisms intrinsic to heart pacemaker cells contribute to age‐associated alterations in heart rate variability in vivo. Aging cell 15: 716-24, 2016.

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Okamoto Y, Lipstein N, Hua Y, Lin KH, Brose N, Sakaba T, Midorikawa M*. Distinct modes of endocytotic presynaptic membrane and protein uptake at the calyx of Held terminal of rats and mice. eLife 5: e14643. 2016

 

Malagon G, Miki T, Llano I, Neher E, Marty A*. Counting vesicular release events reveals binomial release statistics at single glutamatergic synapses. J Neurosci 36: 4010-4025, 2016.

 

Nakao A†, Miki T†, Shoji H, Nishi M, Takeshima H, Miyakawa T*, Mori Y*. Comprehensive behavioral analysis of voltage-gated calcium channel beta-anchoring and -regulatory protein knockout mice. Front Behav Neurosci 9: 141, 2015.

 

Nakao A†, Miki T†, Shimono K, Oka H, Numata T, Kiyonaka S, Matsushita K, Ogura H, Niidome T, Noebels JL, Wakamori M, Imoto K, Mori Y*. Compromised maturation of GABAergic inhibition underlies abnormal network activity in the hippocampus of epileptic Ca²⁺ channel mutant mice, tottering. Pflugers Arch 467: 737-752, 2015.

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Midorikawa M, Okamoto Y, Sakaba T*. Developmental changes in Ca2+ channel subtypes regulating endocytosis at the calyx of Held. J Physiol 592: 3495-510. 2014

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Yaniv Y*, Ahmet I, Liu J, Lyashkov AE, Guiriba TR, Okamoto Y, Ziman BD, Lakatta EG*. Synchronization of sinoatrial node pacemaker cell clocks and its autonomic modulation impart complexity to heart beating intervals. Heart Rhythm 11:1210-1219, 2014.

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Beguin P, Nagashima K, Mahalakshmi R, Vigot R, Matsunaga A, Miki T, Ng M, Ng Y, Lim C, Tay H, Hwang L, Firsov D, Tang B, Inagaki N, Mori Y, Seino S, Launey T*, Hunziker W*. BARP suppresses voltage-gated calcium channel activity and Ca2+-evoked exocytosis. J Cell Biol 205: 233-249, 2014.

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Okamoto Y, Kawamura K, Nakamura Y, Ono K*. Pathological impact of hyperpolarization-activated chloride current peculiar to rat pulmonary vein cardiomyocytes. J Mol Cell Cardiol 66: 53-62, 2014.

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Miki T, Hirai H, Takahashi T*. Activity-dependent neurotrophin signaling underlies developmental switch of Ca2+ channel subtypes mediating neurotransmitter release. J Neurosci 33: 18755-18763, 2013.

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Adachi T, Shibata S, Okamoto Y, Sato S, Fujisawa S, Ohba T, Ono K*. The mechanism of increased postnatal heart rate and sinoatrial node pacemaker activity in mice. J Physiol Sci 63: 133-46. 2013.

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Zhang C, Okamoto Y, Ohba T, Ishibashi K, Yamamoto H, Ono K, Yamamoto F*. Down-regulation of L-type Ca2+ current in left atrial myocytes of rats during experimental cardiac hypertrophy. Akita J Med 39: 61-71, 2012.

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Tadmouri A, Kiyonaka S, Barbabo M, Rousset M, Fablet K, Sawamura S, Bahembera E, Pernet-Gallay K, Arnoult C, Miki T, Sadoul K, Gory-Faure S, Lambrecht C, Lesage F, Akiyama S, Khochbin S, Baulande S, Janssens V, Andrieux A, Dolmetsch R, Ronjat M*, Mori Y, De Waard M*. Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy. EMBO J 31: 3730-3744, 2012. 

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Katano M, Numata T, Aguan K, Hara Y, Kiyonaka S, Yamamoto S, Miki T, Sawamura S, Suzuki T, Yamakawa K, Mori Y*. The juvenile myoclonic epilepsy-related protein EFHC1 interacts with the redox-sensitive TRPM2 channel linked to cell death. Cell Calcium 51: 179-185, 2012. 

 

Uriu Y, Kiyonaka S, Miki T, Yagi M, Akiyama S, Mori E, Nakao A, Beedle AM, Campbell KP, Wakamori M, Mori Y*. Rab3-interacting molecule gamma isoforms lacking the Rab3-binding domain induce long lasting currents but block neurotransmitter vesicle anchoring in voltage-dependent P/Q-type Ca2+ channels. J Biol Chem 285: 21750-21767, 2010.

 

Mashimo T*, Ohmori I, Ouchida M, Ohno Y. Tsurumi T, Miki T, Wakamori M, Ishihara S, Yoshida T, Takizawa A, Kato M, Hirabayashi M, Sasa M, Mori Y, Serikawa T. A missense mutation of the gene encoding voltage-dependent sodium channel (Nav1.1) confers susceptibility to fibrile seizures in rats. J Neurosci 30: 5744-5753, 2010.

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Saito H, Okada M, Miki T, Wakamori M, Futatsugi A, Mori Y, Mikoshiba K, Suzuki N*. Knockdown of Cav2.1 calcium channels is sufficient to induce neurological disorder observed in natural occurring Cacna1a mutants in mice. Biochem Biophys Res Commun 390: 1029-1033, 2009.

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Miyagi K, Kiyonaka S, Yamada K, Miki T, Mori E, Kato K, Numata T, Sawaguchi Y, Numaga T, Kimura T, Kanai Y, Kawano M, Wakamori M, Nomura H, Koni I, Yamagishi M, Mori Y*. A pathogenic C-terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7. J Biol Chem 284: 34400-34412, 2009.

 

Ohmori I*, Ouchida M, Miki T, Mimaki N, Kiyonaka S, Nishiki T, Tomizawa K, Mori Y, Matsui H. A CACNB4 mutation shows that altered Cav2.1 function may be a genetic modifier of severe myoclonic epilepsy in infancy. Neurobiol Dis 32: 349-354, 2008.

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Mizukami Y*, Ono K, Du CK, Aki T, Hatano N, Okamoto Y, Ikeda Y, Ito H, Hamano K, Morimoto S. Identification and physiological activity of survival factor released from cardiomyocytes during ischemia and reperfusion. Cardiovasc Res 79: 589-99, 2008.

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Miki T, Zwingman TA, Wakamori M, Lutz CM, Cook SA, Hosford DA, Herrup K, Fletcher CF, Mori Y, Frankel WN, Letts VA*. Two novel alleles of tottering with distinct Ca(v)2.1 calcium channel neuropathologies. Neuroscience 155: 31-44, 2008. 

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Komatsuda A*, Okamoto Y, Hatakeyama T, Wakui H, Sawada KI. Sulfasalazine-induced hypersensitivity syndrome and hemophagocytic syndrome associated with reactivation of Epstein-Barr virus. Clin Rheumatol 27: 395-7, 2008.

 

Miki T, Kiyonaka S, Uriu Y, De Waard M, Wakamori M, Beedle AM, Campbell KP, Mori Y*. Mutation associated with an autosomal dominant cone-rod dystrophy CORD7 modifies RIM1-mediated modulation of voltage-dependent Ca2+ channels. Channels (Austin) 1: 144-147, 2007.

 

Yamaji N, Sugase K, Nakajima T, Miki T, Wakamori M, Mori Y, Iwashita T*. Solution structure of agelenin, an insecticidal peptide isolated from the spider Agelena opulenta, and its structural similarities to insect-specific calcium channel inhibitors. FEBS Lett 581: 3789-3794, 2007. 

 

Kiyonaka S, Wakamori M, Miki T, Uriu Y, Nonaka M, Bito H, Beedle AM, Mori E, Hara Y, De Waard M, Kanagawa M, Itakura M, Takahashi M, Campbell KP, Mori Y*. RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels. Nat Neurosci 10: 691-701, 2007.